ESTR will be unavailable from 4:00 PM ET on Friday, April 12 until 7:00 AM ET on Monday, April 15. March 28, 2019 Highlights for this release include: Simplified process for single IRB review and management of participating sites, Improved reference and flagging items for reviewers, and Updated workspace views. View the detailed release notes to learn about key changes expected with this update. Read more about ESTR will be unavailable from 4:00 PM ET on Friday, April 12 until 7:00 AM ET on Monday, April 15.